André Brasilier started his artistic studies at the École nationale supérieure des beaux-arts in Paris at the age of 20. During his youth, he won several awards, including the Florence Blumenthal Prize in 1952, but most importantly, the first Grand Prix de Rome in painting a year later, which allowed him to travel and settle at Villa Medici for four years. His first exhibition at the Drouot gallery in Paris had music as its theme.

André Brasilier's artistic style developed throughout his travels and various workshops. He is particularly interested in landscapes and their seasonal variations. His wife is often represented in his works, as are music and animals. Paul Gauguin is considered the "spiritual father" of André Brasilier.

The colors used by André Brasilier vary depending on the theme of his paintings. Ochre, white, and black are used for his musical works, while blocks of blue, green, and black are reserved for the representation of his wife. Greens and blues are used for animals, especially horses. According to André Brasilier, composition is a vital element for a painting to "hold up".

André Brasilier has exhibited in many cities, such as Tokyo, New York, Verden, and Vancouver. In 2005, a retrospective of his work was organized at the Hermitage Museum in Saint Petersburg.